Genespire and SR-TIGET Show Durable Preclinical Efficacy of Liver-Directed Gene Therapy for Methylmalonic Acidemia
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businessQUE Universe Unveils 'Romanticising Indian Everyday' Campaign
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News
Government, corporates and global foundations join hands on PRAGATI to empower 20,000 agri-entrepreneurs
Union Agriculture and Farmers Welfare Minister Shivraj Singh Chouhan recently launched PRAGATI, a nationwide initiative to build 20,000 agri-entrepreneurs and directly benefit 20 lakh smallholder farmers through climate-resilient, regenerative agriculture. Union Minister of Agriculture & Farmers Welfare, Shivraj Singh...
Health
Genespire and SR-TIGET Show Durable Preclinical Efficacy of Liver-Directed Gene Therapy for Methylmalonic Acidemia
Milan, Italy, July 08 -- Genespire, in collaboration with researchers at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), has today announced the publication of preclinical data supporting the potential of its liver-directed immune-shielded lentiviral gene therapy approach to treat methylmalonic acidemia (MMA), a severe inherited metabolic disorder. The findings, published in the Journal of Hepatology, show that a single systemic administration of a lentiviral vector encoding the MMUT gene led to sustained improvements in disease features in a validated mouse model of MMA, with effects lasting for the average lifespan of laboratory mice. Since the mice were treated when young, the study supports the durability of the gene therapy through postnatal growth and maturation of the liver. MMA is caused by a deficiency of methylmalonyl-CoA mutase, an enzyme that plays a critical role in the body’s metabolism of food. Its absence results in the accumulation of toxic metabolites that lead to recurrent metabolic crises, growth failure, neurological impairment, and multi-organ damage. In the study, researchers also treated mice with a dose containing an optimized MMUT transgene, thereby improving therapeutic efficacy. In the same mouse model of MMA, this version exhibited a dose-dependent improvement of metabolomic biomarkers, with gene transfer efficiency exceeding 80% of the liver. The study also highlights that genetically corrected cells in the liver may, over time, replace the diseased ones, suggesting that therapeutic efficacy may progressively improve even when starting at lower initial doses. “Together, these findings indicate that Genespire is on a...
Business
QUE Universe Unveils 'Romanticising Indian Everyday' Campaign
New Delhi, July 08 - QUE Universe, India's new-age fashion eyewear and lifestyle brand, launches a brand campaign, "Romanticising Indian Everyday," inspired by 90s nostalgia, which is going to capture the small, unhurried moments of daily Indian life. Marking...
Assam Simplifies Rules for Small Businesses
Technology
Nothing Unveils Phone 4b
India’s credit card boom: A decade of rapid growth reshapes the way consumers pay
New Delhi, July 8: India’s credit card industry has undergone a remarkable transformation over the past decade, with the number of credit cards issued nearly tripling as consumers increasingly shift towards digital and cashless payment options. The surge reflects a...
Education
New Technology to Help Predict Landslide Risks in Himalayan Region
Mandi, July 8: Researchers at the Indian Institute of Technology Mandi (IIT Mandi) have developed an operational landslide early warning system to improve disaster preparedness in the Indian Himalayan region. The newly developed system will help monitor landslide risks and...
Entertainment
Rajkummar Rao’s Look as Sourav Ganguly Revealed in Upcoming Biopic
Mumbai, July 8: The first-look poster of the upcoming biopic ‘Dada: The Sourav Ganguly Story’ has been released, featuring actor Rajkummar Rao in the role of former Indian cricket captain Sourav Ganguly. The poster was unveiled on Sourav Ganguly’s birthday...
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