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A delegation from Ariel University attended the recent Jewish & Indian Alliance leadership gathering in Tel Aviv, joining entrepreneurs, diplomats, academics, innovators, faith leaders and community representatives from Israel, India and the wider Jewish and Indian diasporas to discuss practical...
Kolkata, July 9 (UDN): Veteran actor Rajesh Sharma remains under close medical observation after developing serious health complications following a suspected insect bite sustained during the shooting of an upcoming Prabhas-starrer at Hyderabad's Ramoji Film City. According to family members,...
New Delhi, July 9: India is strengthening its position as a global technology hub, hosting nearly half of the world’s Global Capability Centres (GCCs) and becoming the second-largest destination for enterprise AI talent, according to the Chief Economic Adviser’s report....
Milan, Italy, July 08 -- Genespire, in collaboration with researchers at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), has today announced the publication of preclinical data supporting the potential of its liver-directed immune-shielded lentiviral gene therapy approach to treat methylmalonic acidemia (MMA), a severe inherited metabolic disorder. The findings, published in the Journal of Hepatology, show that a single systemic administration of a lentiviral vector encoding the MMUT gene led to sustained improvements in disease features in a validated mouse model of MMA, with effects lasting for the average lifespan of laboratory mice. Since the mice were treated when young, the study supports the durability of the gene therapy through postnatal growth and maturation of the liver. MMA is caused by a deficiency of methylmalonyl-CoA mutase, an enzyme that plays a critical role in the body’s metabolism of food. Its absence results in the accumulation of toxic metabolites that lead to recurrent metabolic crises, growth failure, neurological impairment, and multi-organ damage. In the study, researchers also treated mice with a dose containing an optimized MMUT transgene, thereby improving therapeutic efficacy. In the same mouse model of MMA, this version exhibited a dose-dependent improvement of metabolomic biomarkers, with gene transfer efficiency exceeding 80% of the liver. The study also highlights that genetically corrected cells in the liver may, over time, replace the diseased ones, suggesting that therapeutic efficacy may progressively improve even when starting at lower initial doses. “Together, these findings indicate that Genespire is on a...
Mandi, July 8: Researchers at the Indian Institute of Technology Mandi (IIT Mandi) have developed an operational landslide early warning system to improve disaster preparedness in the Indian Himalayan region. The newly developed system will help monitor landslide risks and...

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